An example where we developed a focused set of screens to identify actionable targets in a rare sarcoma.

An example where we developed a focused set of screens to identify actionable targets in a rare sarcoma.

Functional genomics

We use genome editing techniques such as CRISPR-Cas9 to create indels, RNA interference to suppress a gene or overexpression vectors (ORFs) to study the effects of 1 or more genes in the context of cancer.

Cancer types

We have focused our efforts primarily on 2 areas:
1) high risk childhood kidney cancers (e.g. relapsed Wilms tumor, anaplastic Wilms tumor, rhabdoid tumor, renal medullary carcinomas and other rare renal tumors)

2) the high risk childhood brain tumor atypical teratoid rhabdoid tumors

We have other ongoing efforts in soft tissue cancers such as rhabodmyosarcomas and epitheloid sarcomas.

 
Functional Genomics - DepMap@2x.png

Part of a bigger picture

Our models have been incorporated into the larger efforts of identifying cancer vulnerabilities (the human version of the yeast knockout collection) and understanding the biology of cancer.

following up targets

These analyses provide global insight into pan-lineage cancer targets or lineage specific cancer targets.