Our research

overarching goals

Development of new therapies and treatment for our children requires an understanding of the underlying biology and to studying this in the faithful models (e.g. cell lines that grow on plastic or in a mouse, tumor samples from a patient that grow on plastic or in mice or genetically engineered mouse models) of cancer. For some pediatric cancers, such models are lacking and new therapies are needed.

We are developing such models and then confirming that these are genomically faithful to the primary tumors (e.g. whole genome sequencing, whole exome sequencing, RNA-sequencing). We then take these models to look for vulnerabilities using functional genomics (CRISPR-Cas9 gene editing, suppression with RNAi and small molecules).

Click to the left for details on some of our ongoing projects.